Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?
نویسندگان
چکیده
AIMS AND METHODS To describe patients with decreased libido during use of a HMG-CoA-reductase-inhibitor, and to discuss causality and pharmacological hypotheses for this association by analysis of the adverse drug reactions (ADR) database of the Netherlands Pharmacovigilance Centre Lareb. RESULTS Eight patients were identified as having decreased libido during use of statins. In two of these cases testosterone levels were determined and appeared to be decreased. CONCLUSION Decreased libido is a probable adverse drug reaction of HMG-CoA-reductase-inhibitors and is reversible. The ADR may be caused by low serum testosterone levels, mainly due to intracellular cholesterol depletion.
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ورودعنوان ژورنال:
- British journal of clinical pharmacology
دوره 58 3 شماره
صفحات -
تاریخ انتشار 2004